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Moos RH, Solomon GF. Minnesota multiphasic personality inventory response patterns in patients with rheumatoid arthritis. J Psychosom Res. 1964;8:17-28 George Freeman Solomon was born on 25th November 1931 in Freeport,…

It is well known that prevalent chronic kidney disease (CKD) is associated with excess morbidity and mortality compared to non-CKD. Few studies have examined this association in incident CKD….

Rasmussen AF Jr, Marsh JT, Brill NQ. Increased susceptibility to herpes simplex in mice subjected to avoidance-learning stress or restraint. Proc Soc Exp Biol Med. 1957;96:183-189 Aaron Frederick Rasmussen Jr….

The morphological characteristics found in kidneys biopsied of patients with type 2 diabetes (T2DM) and overt nephropathy that predict future progression are increasingly receiving much attention…

A role for rituximab (RTX and other anti-CD19/20 monoclonal antibodies, such as obinutuzumab has been suggested for therapy of steroid-sensitive nephrotic syndrome (SSNS) with a frequently relapsing steroid-dependent (FR/SD) response…

The “primary” form of the focal segmental glomerulosclerosis (FSGS) lesion (commonly associated with the presence of circulating permeability-promoting factors…

It is very clear that monogenetic diseases commonly underlie the clinical entity known as steroid-resistant nephrotic syndrome (SRNS) in both children and adults…

Hench PS. The analgesic effect of hepatitis and jaundice in chronic arthritis, fibrositis, and sciatic pain, Ann Internal Med. 1934:7:1278-1294. Hench PS. The ameliorating effect of pregnancy on chronic atrophic…

Chronic kidney disease (as defined by KDIGO-CKD criteria) is fairly common among living kidney donors subjected to uni-nephrectomy, especially in older donors with age-associated decline in pre-transplant GFR…

Long-term survivors of kidney transplantation suffer from numerous complications. Often, they die due to side effects of immunosuppressive medications…

IgA nephropathy (IgAN) is a common glomerular disease that is not infrequently accompanied by superimposed crescentic glomerulonephritis (GN) of varying severity. Extensive crescentic disease…

Ishigami T. The influence of psychic acts on the progress of pulmonary tuberculosis. Am. Rev. Tuberc. 1919;2:470-484. Tohru Ishigami (1857–1919) was the “discoverer of emotional effects on tuberculosis progression related…

It is not presently known if minimal change disease (MCD) and primary focal and segmental glomerulosclerosis (pFSGS) are separate disease entities or part of a continuous spectrum of a single…

The relationship of blood pressure (BP; systolic, diastolic, pulse pressure, mean arterial pressure) in dialysis patients with diabetes is greatly complicated by competing risks and co-morbidities. Many studies failed…

Because of non-specific symptomatology, Fabry’s disease may elude diagnosis during progression of….

Selye H. Thymus and adrenals in the response of the organism to injuries and intoxications. Brit J Exper Path. 1936;17:234-248 Selye H. Studies on adaptation. Endocrinology 1937;21:169-188 Harlow CM, Selye…

Novel urinary biomarkers for the early prediction of AKI in newly admitted patients to Intensive Care Units (ICU) have been developed but the overall clinical utility of these….

Calciphylaxis (Calcific Uremic Arteriopathy, CUA) is an uncommon but devastating and often fatal complication of…

The search for clinical, laboratory, and histological biomarkers useful for predicting outcomes in IgA nephropahy (IgAN) continues at a fairly rapid pace, but actual progress…

Viral-induced glomerular disease is a very important part of the spectrum of glomerulonephritis, especially since many…

Metalnikov S, Chorine V. Role des reflexes conditionnels dans l’immunite. Ann Inst Pasteur (Paris) 1926;40:893–900 Metalnikov S, Chorine V. Role des reflexes conditionnels dans la formation des anticorps. CR Soc…

Observational, long-term cohort studies can play an important role for generating testable hypotheses to improve our….

The “gold standard” for evaluation of urinary total protein excretion…

The treatment of membranous nephropathy (MN; PLA2R associated) has improved greatly in recent years, but uncertainties still exist concerning the treatment of such patients who have already advanced to stage…

Kidney fibrosis is one of the final common end-points of progressive CKD in both diabetic and non-diabetic patients. But very few studies have attempted to evaluate kidney fibrosis and its…

The therapy of secondary hyperparathyroidism (SHPTH) in patients with advanced chronic kidney disease (CKD) presenting with 25-hydroxyvitamin D deficiency is not well established. Three approaches are …

Persistent high-grade hematuria is associated with an adverse impact on prognosis in IgA Nephropathy (IgAN), independent of proteinuria according to retrospective observational studies…

The definition of chronic kidney disease (CKD) using estimated glomerular filtration (eGFR) equations (indexed to a standard body surface area [BSA] of 1.73 m2) has been recognized as…

Calcium deposition in the kidney parenchyma (using special stains such as the von Kossa stain), also known as dystrophic calcification, is a relatively common finding (about 10%) in native kidney…

Uromodulin (UMOD or Tamm-Horsfall Protein) is synthesized and secreted by the thick ascending limb of the loop of Henle in the kidney. Mutations of the UMOD gene have been linked…