Viewpoint On

Yeaman M.R: Immunosuppression in Glomerular Diseases: Implications for SARS-CoV-2 Vaccines and COVID-19. Glomerular Diseases DOI 10.1159/000519182

Patients with chronic glomerulonephritis (GN) often have underlying immunological abnormalities that can be further altered by concomitant immunosuppressive (IS) therapy. In the era of the COVID-19 pandemic these changes can impact the ability of COVID vaccines to impart protective immunity, influence susceptibility to SARS-CoV-2 infection, and influence the natural clinical evolution of COVID-19.

In a very scholarly, comprehensive, and well-written review, Dr. Yeaman has summarized these issues in a very useful and understandable fashion. It is difficult to do justice to this elegant presentation in only a few short words. Physicians caring for patients with GN who are also receiving IS agents and who are concerned about COVID-19 infections or COVID vaccine administration should read this review in the original form. The effects of uremia itself, steroids, alkylating agents, anti-metabolites, calcineurin inhibitors, mTOR inhibitors, and CD38 monoclonal antibodies are discussed. Strategies to optimize the safety and effectiveness of COVID-19-preventative measures in patients with GN receiving IS treatment are also stressed. Altogether, a timely and highly relevant contemporary review of a subject of immense global importance.

Quoted Karger Article

Immunosuppression in Glomerular Diseases: Implications for SARS-CoV-2 Vaccines and COVID-19

Related Posts

Moos RH, Solomon GF. Minnesota multiphasic personality inventory response patterns in patients with rheumatoid arthritis. J Psychosom Res. 1964;8:17-28 George Freeman Solomon was born on 25th November 1931 in Freeport,…

It is well known that prevalent chronic kidney disease (CKD) is associated with excess morbidity and mortality compared to non-CKD. Few studies have examined this association in incident CKD….

Rasmussen AF Jr, Marsh JT, Brill NQ. Increased susceptibility to herpes simplex in mice subjected to avoidance-learning stress or restraint. Proc Soc Exp Biol Med. 1957;96:183-189 Aaron Frederick Rasmussen Jr….