Viewpoint On

Yeaman M.R: Immunosuppression in Glomerular Diseases: Implications for SARS-CoV-2 Vaccines and COVID-19. Glomerular Diseases DOI 10.1159/000519182

Patients with chronic glomerulonephritis (GN) often have underlying immunological abnormalities that can be further altered by concomitant immunosuppressive (IS) therapy. In the era of the COVID-19 pandemic these changes can impact the ability of COVID vaccines to impart protective immunity, influence susceptibility to SARS-CoV-2 infection, and influence the natural clinical evolution of COVID-19.

In a very scholarly, comprehensive, and well-written review, Dr. Yeaman has summarized these issues in a very useful and understandable fashion. It is difficult to do justice to this elegant presentation in only a few short words. Physicians caring for patients with GN who are also receiving IS agents and who are concerned about COVID-19 infections or COVID vaccine administration should read this review in the original form. The effects of uremia itself, steroids, alkylating agents, anti-metabolites, calcineurin inhibitors, mTOR inhibitors, and CD38 monoclonal antibodies are discussed. Strategies to optimize the safety and effectiveness of COVID-19-preventative measures in patients with GN receiving IS treatment are also stressed. Altogether, a timely and highly relevant contemporary review of a subject of immense global importance.

Quoted Karger Article

Immunosuppression in Glomerular Diseases: Implications for SARS-CoV-2 Vaccines and COVID-19

Related Posts

Besedovsky H, Sorkin E, Keller M, Müller J. Changes in blood hormone levels during the immune response. Proc Soc Exp Biol Med. 1975;150:466-470. doi: 10.3181/00379727-150-39057. PMID: 1208563. Hugo Oscar Besedovsky…

Smith EM, Blalock JE. Human leukocyte production of corticotropin and endorphin-like substances: Association with leukocyte interferon. Proc. Natl. Acad. Sci. USA 1981;78:7530-7534 J. Edwin Blalock received his B.S. and Ph.D….

The SickKids Handbook of Pediatric Thrombosis and Hemostasis covers the entire field of pediatric thrombosis and hemostasis. It was written to give pediatric clinicians who have to deal with a…