Discover thought-provoking research from a wide range of medical and health sciences disciplines across our diverse portfolio.
Long-term survivors of kidney transplantation suffer from numerous complications. Often, they die due to side effects of immunosuppressive medications…
IgA nephropathy (IgAN) is a common glomerular disease that is not infrequently accompanied by superimposed crescentic glomerulonephritis (GN) of varying severity. Extensive crescentic disease…
December 14, 2023
Pillar Articles Series: The Influence of Adrenaline and Emotional Excitement on Phagocytosis of Tubercle Bacilli
Ishigami T. The influence of psychic acts on the progress of pulmonary tuberculosis. Am. Rev. Tuberc. 1919;2:470-484. Tohru Ishigami (1857–1919) was the “discoverer of emotional effects on tuberculosis progression related…
December 14, 2023
Rituximab in Minimal Change Disease and Primary Focal and Segmental Glomerulosclerosis
It is not presently known if minimal change disease (MCD) and primary focal and segmental glomerulosclerosis (pFSGS) are separate disease entities or part of a continuous spectrum of a single…
The relationship of blood pressure (BP; systolic, diastolic, pulse pressure, mean arterial pressure) in dialysis patients with diabetes is greatly complicated by competing risks and co-morbidities. Many studies failed…
Because of non-specific symptomatology, Fabry’s disease may elude diagnosis during progression of….
November 7, 2023
Pillar Articles Series: Severe Stress Contracts Lymphoid Organs and Changes Leukocyte Blood Count
Selye H. Thymus and adrenals in the response of the organism to injuries and intoxications. Brit J Exper Path. 1936;17:234-248 Selye H. Studies on adaptation. Endocrinology 1937;21:169-188 Harlow CM, Selye…
Novel urinary biomarkers for the early prediction of AKI in newly admitted patients to Intensive Care Units (ICU) have been developed but the overall clinical utility of these….
Calciphylaxis (Calcific Uremic Arteriopathy, CUA) is an uncommon but devastating and often fatal complication of…
The search for clinical, laboratory, and histological biomarkers useful for predicting outcomes in IgA nephropahy (IgAN) continues at a fairly rapid pace, but actual progress…
Viral-induced glomerular disease is a very important part of the spectrum of glomerulonephritis, especially since many…
Metalnikov S, Chorine V. Role des reflexes conditionnels dans l’immunite. Ann Inst Pasteur (Paris) 1926;40:893–900 Metalnikov S, Chorine V. Role des reflexes conditionnels dans la formation des anticorps. CR Soc…
Observational, long-term cohort studies can play an important role for generating testable hypotheses to improve our….
The “gold standard” for evaluation of urinary total protein excretion…
The treatment of membranous nephropathy (MN; PLA2R associated) has improved greatly in recent years, but uncertainties still exist concerning the treatment of such patients who have already advanced to stage…
Kidney fibrosis is one of the final common end-points of progressive CKD in both diabetic and non-diabetic patients. But very few studies have attempted to evaluate kidney fibrosis and its…
The therapy of secondary hyperparathyroidism (SHPTH) in patients with advanced chronic kidney disease (CKD) presenting with 25-hydroxyvitamin D deficiency is not well established. Three approaches are …
Persistent high-grade hematuria is associated with an adverse impact on prognosis in IgA Nephropathy (IgAN), independent of proteinuria according to retrospective observational studies…
The definition of chronic kidney disease (CKD) using estimated glomerular filtration (eGFR) equations (indexed to a standard body surface area [BSA] of 1.73 m2) has been recognized as…
Calcium deposition in the kidney parenchyma (using special stains such as the von Kossa stain), also known as dystrophic calcification, is a relatively common finding (about 10%) in native kidney…
Uromodulin (UMOD or Tamm-Horsfall Protein) is synthesized and secreted by the thick ascending limb of the loop of Henle in the kidney. Mutations of the UMOD gene have been linked…
Accurate and reproducible prediction of the long-term (5–10 years) outcomes in individuals or groups of patients with biopsy-proven IgA nephropathy (IgAN) is a very desirable goal…..
Fibrillary glomerulonephritis (FGN) is a rare form of primary glomerular disease defined by the common co-deposition of IgG and DNAJB9 and fibril formation. Its etiology and pathogenesis are unknown…
Prediction of the long-term outcomes in individual patients with IgA nephropathy (IgAN) using pathological parameters has long been a “holy grail” in Nephrology….
The COVID-19 pandemic unleashed a new wave (indeed a torrent) of an old and well-recognized phenomenon; namely, the development of de novo or an exacerbation of underlying kidney disease in…
Anti-GBM disease poses a serious threat to survival and preservation of kidney function, especially if it is discovered or treated late in its evolution. It is a rare disease…
Various definitions of acute kidney injury (AKI) are in common use, globally. But comparisons of the utility of these definitions for AKI following cardiac surgery have come to….
The optimum dosage and preparation of renin-angiotensin system inhibitors (RASi) for slowing the progression of progressive proteinuric CKD remains somewhat uncertain,..
The comparative effectiveness of various modalities of dialysis in patients with kidney failure has long been controversial, in large part due to the paucity of long-term randomized clinical trials….
Sodium balance in patients with kidney failure treated by dialysis is highly variable and incompletely understood, in pathophysiological terms. Sodium excess is linked both to hypertension and…