Calciphylaxis is a serious, potentially life-threatening complication of ESRD that may be precipitated (or aggravated) by vitamin K antagonists (such as warfarin) used for necessary anticoagulation. Alternative non-warfarin anti-coagulation strategies…

The relationships between sodium chlorid (NaCl) intake and clinical outcomes in hemodialysis patients (such as mortality rates) are…

An adaptation of magnetic resonance imaging (MRI) technology has made it possible to non-invasively asses…

Albuminuria, even in the high normal range (> 10 and < 30 mg/d), is associated with the presence or development of…

Surprisingly, the normal limits of venous serum total CO2 (tCO2; a surrogate for serum HCO3- concentration) in adults are not well established…

The current estimating equations for glomerular filtration rate (GFR) exhibit consistent inaccuracies (bias and precision) and as a result…

The dialysis treatment session length (DSL) in conventional thrice weekly hemodialysis therapy has been long suspected to contribute importantly to…

The presence of CKD in adults (mostly older) is a common global problem, although the precise incidence and prevalence of CKD, the changes in frequency over-time and its variation between…

It is generally accepted that systemic inflammatory processes can enhance or induce proteinuria, especially in subjects with pre-existing glomerular disorders. However, much less is known…

The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guidelines recommend confirmatory testing for estimated glomerular filtration rate (eGFR) using cystatin C or…

The intestinal microbiome has become a facet of human biology that is attracting great interest, including among investigators in the field of kidney disease. In CKD, “uremic” toxins may be…

The optimal management of ischemic coronary artery disease in patients with end-stage renal disease (ESRD) awaiting renal transplantation remains as a conundrum. Avoidance of a cardiovascular (CV) death following renal…

The ability to reliably and accurately predict the response to treatment of glomerular disease with specific regimens would be a great advance…

Disturbances of acid-base homeostasis very commonly complicate critical illnesses. Arterial blood gases (ABG) combined with assessment of serum electrolytes (especially the anion gap and delta bicarbonate) are traditionally used…

Left ventricular hypertrophy (LVH) is common in chronic kidney disease (CKD) and in end-stage renal disease (ESRD) treated by dialysis. The failure of LVH to regress or its progression can…

In a very remarkable retrospective “registry-based” study, Hou and colleagues examined the changes in the spectrum of kidney disease derived from careful study of 40,759 native kidney biopsies…